Xanthohumol-Enriched Beer Does Not Exert Antitumorigenic Effects on HeLa Cell Line In Vivo.

Xanthohumol is a hop-derived flavonoid that has been widely examined for its health-protecting and antitumorigenic properties, but not yet in a natural beer matrix. The aim of the study was to investigate the antitumorigenic potential of a xanthohumol-enriched beer in vivo. Four groups of 4 × 10 nude mice were formed. Following the injection of HeLa tumorigenic cell lines, the treatment groups were administered a xanthohumol supplementation for 100 days, either dissolved in beer or in an ethanolic solution with the same alcohol strength as beer. The control groups received un-supplemented material. The terminal tumor masses, liver weights, and plasma antioxidant capacities (FRAP and ABTS methods) were measured. For the statistical analysis, a two-way ANOVA test was performed (p < 0.05). There were no statistically significant differences in tumor size between the groups. Xanthohumol did not induce higher levels of plasma antioxidant capacity, neither in beer nor in the water-ethanol matrix. The terminal liver weights were significantly higher in the control group receiving the unsupplemented ethanol solution. Xanthohumol dissolved in beer or in the water-alcohol matrix did not have a protective effect on tumor growth, nor did it have a positive effect on plasma antioxidant capacity either. However, beer with added xanthohumol had a less harmful effect on the liver compared to the supplemented water-ethanol solution. Our results indicate the possible negative countereffect of ethanol; however, further investigations are needed.

The low FODMAP diet supported by a mobile application for functional gastrointestinal and inflammatory bowel diseases / A mobilapplikációval támogatott alacsony-FODMAP-étrend a funkcionális gastrointestinalis és a gyulladásos bélbetegségek kezelésében

Diseases affecting the gastrointestinal tract such as functional gastrointestinal diseases ­ including irritable bowel syndrome ­ as well as inflammatory bowel diseases are on the rise in Hungary. More and more nutritional recommendations are emerging as part of the therapy, but so far there is no uniform recommendation for the dietary management of these gastrointestinal diseases. Among the dietary recommendations that have been made so far, the low FODMAP diet is noteworthy. FODMAP itself stands for the abbreviation of the initials of fermentable, short-chain, poorly absorbable carbohydrates: fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP). The low FODMAP diet is a scientifically and clinically proven therapeutic recommendation, which is supported in Hungary by the Ministry of Human Resources Guideline (2020). Research has shown that the low FODMAP diet has been shown to reduce gastrointestinal symptoms. The diet consists of 3 phases, the first of which is a step-by-step list of trigger and non-trigger foods that the doctor, with the help of a dietitian, determines. As this stage of the diet can be the most challenging, it is worth emphasizing that it should be developed in collaboration with a dietitian. The aim of the diet is to find a balance between keeping symptoms at a low level and expanding the diet. Low FODMAP diet has been shown to be an effective, successful, and accepted nutritional intervention in the management of symptoms of functional and inflammatory bowel disease. Its use can improve the success of pharmacological interventions and increase patient compliance, hence the need to expand the widespread dissemination of the diet. A mobile app developed by a research team at Monash University will support self-management and practical implementation of the diet and increase adherence to nutritional therapy.

Influence of cognitive function and nurse support on malnutrition risk in nursing home residents.

AIM: To predict malnutrition risk of older residents by cognitive function, nurse support and self-care capacity as primary measures of interest. DESIGN: Cross-sectional, correlation design with linear regression analysis. METHODS: Older residents over 60 years of age were randomly selected from nursing homes. Mini Mental State Exam and the Mini Nutritional Assessment were used were as main measures. RESULTS: Lower malnutrition risk was associated with better cognitive functioning. Improved independence of self-feeding was also linked to reduced nutritional risk. Nurse support was positively related to BMI and cognitive impairment. General self-care capacity and 'appetite the week before' were key predictors of malnutrition risk; 1-point increase in both variables caused nutritional risk to decrease by 1.73 and 1.38 points, respectively. That is, a 1-point increase in self-care capacity and appetite would decrease malnutrition risk by 5.76% and 4.6%. The regression model explained significant amount (65.6%) of variance in malnutrition risk.

Substantial variation across geographic regions in the obesity prevalence among 6-8 years old Hungarian children (COSI Hungary 2016).

BACKGROUND: There have been previous representative nutritional status surveys conducted in Hungary, but this is the first one that examines overweight and obesity prevalence according to the level of urbanization and in different geographic regions among 6-8-year-old children. We also assessed whether these variations were different by sex. METHODS: This survey was part of the fourth data collection round of World Health Organization (WHO) Childhood Obesity Surveillance Initiative which took place during the academic year 2016/2017. The representative sample was determined by two-stage cluster sampling. A total of 5332 children (48.4% boys; age 7.54 ± 0.64 years) were measured from all seven geographic regions including urban (at least 500 inhabitants per square kilometer; n = 1598), semi-urban (100 to 500 inhabitants per square kilometer; n = 1932) and rural (less than 100 inhabitants per square kilometer; n = 1802) areas. RESULTS: Using the WHO reference, prevalence of overweight and obesity within the whole sample were 14.2, and 12.7%, respectively. According to the International Obesity Task Force (IOTF) reference, rates were 12.6 and 8.6%. Northern Hungary and Southern Transdanubia were the regions with the highest obesity prevalence of 11.0 and 12.0%, while Central Hungary was the one with the lowest obesity rate (6.1%). The prevalence of overweight and obesity tended to be higher in rural areas (13.0 and 9.8%) than in urban areas (11.9 and 7.0%). Concerning differences in sex, girls had higher obesity risk in rural areas (OR = 2.0) but boys did not. Odds ratios were 2.0-3.4 in different regions for obesity compared to Central Hungary, but only among boys. CONCLUSIONS: Overweight and obesity are emerging problems in Hungary. Remarkable differences were observed in the prevalence of obesity by geographic regions. These variations can only be partly explained by geographic characteristics. TRIAL REGISTRATION: Study protocol was approved by the Scientific and Research Ethics Committee of the Medical Research Council ( 61158-2/2016/EKU ).

[Support of diabetes dietary management and self-management using mobile applications]. / Diabetesesek dietoterápiájának és önmenedzselésének támogatása mobilapplikációk használatával.

The key components of successful diabetes therapy are pharmacotherapy, hospital care and lifestyle education. Lifestyle education, self-management, and composing the right diet can be effectively supported with mobile applications. In this paper Hungarian mobile applications are reviewed and compared to some international competitors. Besides plenty of useful functions some deficiencies are identified, based on dietary recommendations. The related improvements together with clinical trials validating effectiveness and reliability can strengthen medical evidence as well as the penetration of such mobile applications. Orv. Hetil., 2016, 157(29), 1147-1153.